By Spacing out spaceflights may benefit astronauts’ brains.
While outside Earth’s atmosphere, fluid-filled chambers in the brains of astronauts tend to adapt to microgravity by expanding. But after a space mission, these structures might take three years to shrink back to normal, researchers report June 8 in Scientific Reports. The finding suggests that astronauts might need at least that much time between flights before their brains are ready to be in space again.
At the brain’s center sit four cavities — or ventricles — brimming with liquid that cushions the organ and clears out waste. But with little gravity in space, fluids accumulate in an astronaut’s head. So the ventricles adapt by taking in more fluid and expanding, says space scientist Rachael Seidler of the University of Florida in Gainesville.
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Researchers knew that astronauts often return to Earth with enlarged ventricles. But Seidler and colleagues wanted to see if time spent in space or how much time had elapsed since past flights affect how much the brain changes during a mission.
The team examined MRI brain scans of 30 astronauts from before and after one of each astronaut’s missions. Analysis showed that the longer the mission, the more three of the four ventricles seemed to expand. The fourth ventricle is so small that possible volume changes may have been too tiny to detect, Seidler says. While two-week trips left a minimal mark on ventricles, six- and 12-month missions resulted in enlargement by fractions of a milliliter. The two longer durations led to similar amounts of expansion, suggesting the swelling slows after six months in space.
For the 18 astronauts who had flown before, time between missions also appeared to make a difference. In those who last visited space three to nine years prior, three of their ventricles expanded — on average, roughly 10 to 25 percent — during the mission that the researchers studied. But ventricles grew little to none in astronauts whose last spaceflight took place less than three years prior, which suggests their brains may not have had enough time between missions to fully recover, the scientists say.
“I’m glad that the [study] authors took the first step and are looking at this question,” says neuroradiologist Donna Roberts of the Medical University of South Carolina in Charleston. “There are so many variables that could play into the brain changes that we’re seeing, and it’s hard to sort them out.”
Spaceflight’s effects on the brain are even more pressing now that NASA aims to send people to Mars, which could be a two-year round trip, she notes (SN: 12/1/22). “Everybody talks about the rocket technology to get to Mars,” Roberts says. But “the humans — that’s the real challenge.”
